Flux balance modeling to predict bacterial survival during pulsed-activity events

Jose, Nicholas A.; Lau, Rebecca; Swenson, Tami L.; Klitgord, Niels; Garcia-Pichel, Ferran; Bowen, Benjamin P.; Baran, Richard; Northen, Trent R.

doi:https://doi.org/10.5194/bg-15-2219-2018

Articles | Volume 15, issue 7

https://doi.org/10.5194/bg-15-2219-2018

© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/bg-15-2219-2018

© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 15, issue 7

Research article

|

16 Apr 2018

Research article |

| 16 Apr 2018

Flux balance modeling to predict bacterial survival during pulsed-activity events

Nicholas A. Jose, Rebecca Lau, Tami L. Swenson, Niels Klitgord, Ferran Garcia-Pichel, Benjamin P. Bowen, Richard Baran, and Trent R. Northen

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Final revised paper (published on 16 Apr 2018)
Supplement to the final revised paper
Preprint (discussion started on 19 Oct 2017)
Supplement to the preprint

Interactive discussion

Status: closed

AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment

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- Supplement

RC1: 'Metabolic reconstruction for Microcoleus vaginatus', Anonymous Referee #1, 31 Oct 2017
- AC1: 'Reply to anonymous referee #1', trent northen, 18 Nov 2017
  - RC2: 'Flux balance modelling to predict bacterial survival during pulsed activity events', Anonymous Referee #1, 22 Nov 2017
    - AC2: 'Response to reviewer 1', trent northen, 05 Dec 2017
      - RC3: 'Flux balance modelling to predict bacterial survival during pulsed activity events', Anonymous Referee #1, 05 Dec 2017
        
        AC4: 'Reply to anonymous referee #1', trent northen, 16 Feb 2018
RC4: 'Review', Anonymous Referee #2, 30 Jan 2018
- AC3: 'Reply to anonymous referee #2', trent northen, 16 Feb 2018

Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision

ED: Publish subject to minor revisions (review by editor) (18 Feb 2018) by Kees Jan van Groenigen

AR by trent northen on behalf of the Authors (27 Feb 2018) Author's response Manuscript

ED: Publish as is (22 Mar 2018) by Kees Jan van Groenigen

AR by trent northen on behalf of the Authors (29 Mar 2018)

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Short summary

Microcoleus vaginatus, a filamentous cyanobacteria, is a primary producer and pioneer in desert biological soil crusts (BSCs). Previous studies have suggested that biopolymers play a central role in M. vaginatus' ability to survive in arid conditions. We have developed a genome-scale metabolic model with experimental validation to elucidate the mechanism of this phenomenon and predict survival during pulsed-activity events, providing a basis for future modeling of BSCs.